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Hyaluronan fragments act as an endogenous danger signal by engaging TLR2

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In just over 640 pages, the 1988 US Surgeon Generals report set out the evidence that nicotine was an addictive drug.[24] Eventually, this led to an investigation by the Food and Drug Administration in the mid-1990s seeking to deem, and then control, any new devices as drug delivery systems and so subject them to medical regulation

I also wrote a passionate commentary in 1990 in the Chronicle of Higher Education urging universities, especially those with medical schools, to eliminate tobacco stocks from their investment portfolios