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J.LausoontornsiriW.et al (2017)

Clustering cells increase the expression of matrix-degrading enzymes 11,21,41 and a relatively high proportion of them are senescent 42,43

[1] The results were exciting: [1] While L-citrulline alone increased plasma arginine, the combination with glutathione was most effective at increasing plasma nitrite and nitric oxide metabolites (NOx)