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Pleural Mesothelioma Symptoms The most common symptoms that pleural mesothelioma patients develop first include: As the cancer grows and spreads, other symptoms develop or worsen including: Coughing or wheezing Shortness of breath (dyspnea) Chest pain Pleural effusion (fluid around the lungs) Fever or night sweats Fatigue Muscle weakness Unexplained weight loss Loss of appetite Trouble swallowing (dysphagia) Many of these symptoms may initially lead doctors to misdiagnose pleural mesothelioma as pneumonia, chronic bronchitis or adenocarcinoma

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