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Br J Cancer 91(7):12801286

A second trial, comparing normal subjects and subjects with moderatetosevere renal impairment (GFR 30.9 10.8 mL per min), showed that after a single 150mg dose of sustained-release bupropion, exposure to bupropion was approximately 2-fold higher in subjects with impaired renal function while levels of the hydroxybupropion and threo/erythrohydrobupropion (combined) metabolites were similar in the 2 groups

Individuals with bipolar disorder may turn to drugs or alcohol to manage their symptoms, such as depression or anxiety, or to cope with the side effects of their medications