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The FDA in June 2022 also announced that JUULs applications lacked sufficient evidence regarding the toxicological profile of the products to demonstrate that marketing of the products would be appropriate for the protection of the public health. The agency has also recently noted that scientific issues unique to its application warrant additional review and stated that the company still cannot legally market or sell its products

Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]

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These materials resist corrosion and help maintain oil purity