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A prospective study demonstrated that patients with small airway disease (SAD) defined by impulse oscillometry (IOS) experienced a more rapid decline in lung function and a greater risk of acute exacerbations (112)

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We will still be adequately powered to make comparisons between these scenarios, and by shifting to 2 scenarios while retaining our total target enrollment, we will have higher numbers of individuals in these groups than planned which could allow us to evaluate additional moderating factors by subgroups, such as sex or age