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For additional background, you can review this PubMed overview on GHK and tissue remodeling

This allows for the inclusion of copper peptide ghk-cu in formulations designed for sensitive or reactive skin types, providing strengthening benefits without the sting associated with high concentrations of free metal ions

Both glucose and insulin signaling have been reported to regulate Cyp7a1 expression in liver 12

Avoid using on broken or compromised skin: While copper peptides aid wound healing, they should not be applied to open wounds, active infections, or severely irritated skin unless advised by a dermatologist