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Nicotine primarily affects the peripheral and central nervous systems

Cannabis use frequency is not associated with higher risk of conversion when controlling for tobacco use To isolate the contributions of cannabis and tobacco use individually on conversion to psychosis, we performed analyses using cannabis or tobacco use frequency as a predictor while controlling for use of the other substance

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[94] Long-term nicotine exposure upregulates cortical nicotinic receptors, but it also lowers the activity of the nicotinic receptors in the cortical vasodilation region