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GSH inhibits PSC activation and proliferation induced by LOsG in vivo and in vitro PSC activation is a critical event in pancreatic fibrosis, and activated PSCs have characteristics such as high proliferation and increased ECM secretion

The essential role of glutathione in plant development has been demonstrated by the mutant rml1 which is impaired in GSH1 and produces approximately 3% of wild type glutathione levels, leading to extremely short roots 55

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