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Nicotine is consumed primarily through smoking, vaping, or using smokeless tobacco products, where it is rapidly absorbed into the bloodstream, delivering an immediate effect on the brain

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17 Although there have been concerns about neuropsychiatric adverse effects with varenicline, the evidence from a recent meta-analysis is that, compared with placebo, there is no increase in rates of suicidal events, depression or aggression/agitation in patients taking varenicline

Pediatricians and adolescent medicine specialists are strategically positioned to identify and intervene in early nicotine use