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Using two incretin-based compounds simultaneously would create overlapping receptor activation at the GLP-1 and GIP sites, dramatically increasing side effect risk without proportional efficacy gains

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a number of the agonists in Table 1 (Families 2-5) have norleucine at Rj, or an amino acid residue a number of an amino acid residues (D or L) may be used at residue Ri, including without limitation, tyrosine, phenylalanine, aspartic acid, arginine, isoleucme, serine, histidine, glycine, cysteine, methionine, tryptophan, norvaline, ornithine, S-benzyl cysteine amino acid residues

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