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Tobacco-specific N -nitrosamines and Areca -derived N -nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans

2020;29:e12902

King and Corkery 5 suggested an index of fatal toxicity for drugs of misuse that was calculated as the ratio of the number of deaths associated with a substance to its availability

Arguments ranged from socio-economic, with tobacco called a usurper of good farmland, to purely moralistic, where many religiously devout individuals saw tobacco as another form of immoral intoxication