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Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial

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Patients on this combination should have baseline IGF-1 and CBC checked, with follow-up labs at 4 to 6 weeks and a low threshold for anti-Xa measurement if any clinical concern arises

doi:10.1186/s40425-016-0139-8 Boutros, C., Tarhini, A., Routier, E., Lambotte, O., Ladurie, F.L., Carbonnel, F.,