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This orthogonal mechanism makes the combination a research model for studying receptor cross-talk in neuroendocrine signaling

doi: 10.1080/19336918.2019.1629224 31 CardonaA

JAKs can link to multiple STATs, with STATs being the final effectors of signaling, and the combinations can be activated to regulate transcription, mediating processes like apoptosis, proliferation, differentiation, and cell migration [117, 118]