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This work was funded by the National Institute of Health (1R35GM147266-01 to N.T.), Whitehall Foundation (2022-05-080 to N.T.), and American Heart Association ( to G.S.-C.)

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HCG and Male Reproductive Research Research has confirmed the utility of hCG in pre-clinical models of male hypogonadism driven by impaired HPG axis signalling including conditions where exogenous hormone exposure has suppressed pulsatile GnRH and LH secretion, reducing Leydig cell testosterone output and intratesticular testosterone levels