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There are several signaling pathways, such as the phosphoinositide 3-kinases (PI3K)/protein kinase-B (Akt) pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)/nuclear factor kappa B (NF-B) pathway, which demonstrates a decrease in the inflammatory reaction and mediators upon activation of 7nAChRs [35, 36]

Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH

This finding supports our hypothesis that NRF2 plays a protective role in the development of psoriasis and that SFN acts via NRF2-related pathways

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