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Many things can lead to it, including: Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or naproxen Overuse of alcohol, tobacco, or cocaine Repeated vomiting Stress, such as that caused by an injury, surgery, or serious illness Infections caused by bacteria such as H

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[179] [248] Nicotine suppresses the innate and adaptive immune response by reducing the secretion of pro-inflammatory cytokines (IL-1, IL-6, TNF-, IL-17, IL-21, and IL-22), reducing proliferation and activation of T-cells, and suppressing the activation of dendritic cells