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A 2022 meta-analysis in Frontiers in Endocrinology pooled 14 trials of GLP-1 receptor agonists and antioxidant outcomes and concluded that GLP-1 agonists reduce oxidative stress markers independent of weight loss or glucose lowering

**NRV (napi beviteli referenciartk)

DNA demethylation upregulated Nrf2 expression in Alzheimers disease cellular model

Below is a hypothetical scenario to demonstrate my point: An individual suffers from long-term thiamine deficiency and has suboptimal riboflavin status Thiamine deficiency leads to lower activity of transketolase Low transketolase activity produces a lack of NADPH A lack of NADPH and a lack of FAD means that glutathione reductase is unable to efficiently recycle glutathione, which produces an imbalance between reduced/oxidized glutathione