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(2012) in Drug and Alcohol Dependence , proposes that a latent underlying vulnerability shaped by genetic polymorphisms, early environmental adversity, and neurobiological temperament predisposes individuals to substance use disorders across all drug classes simultaneously

Danes continued: "I knew he was wrestling with the decision to do that movie or not, and he looked up at me and said, 'I'm doing it.' I could see he wasn't sure, but he was like 'F*** it, I've got to do this thing.' I looked at him like I totally understand why he wanted to do that, but I'm not ready for that