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Similarly, a study using a mouse model found that PNE produced hyperactivity that was associated with selective decreases in cingulate cortical volume and radial thickness and a decrease in drug-induced dopamine release in the frontal cortex [36]

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[64] Ibid., 63 [65] "Reports of the Regional Governors - Central Region," Proceedings from the 50 th Annual Meetings of the National Tobacco Tax Association (Chicago: Federation of Tax Administrators, 1976), 98

They found a one percent change in flow-mediated dilation (FMD) which translates to a 14 percent lower rate of cardiovascular disease