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Effectiveness of CHANTIX versus other drugs Varenicline's approval was supported by six clinical trials that enrolled a total of nearly 3,700 chronic smokers who were treated with varenicline, bupropion (ZYBAN) another oral smoking cessation drug that contains the same active ingredient found in the antidepressant drug WELLBUTRIN or a placebo

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The rate of periodontitis among those who have never smoked is 4.9 percent as opposed to 10.5 percent for former smokers and 15.6 percent for current smokers

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