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Of the several lysosomal proteins, variants of the major lysosomal enzyme GBA1 are implicated with increased PD risk (Atashrazm et al., 2018)

Accordingly, synthetic mimics of seleno-GPxs, as discussed in previous sections, appear to be ideal candidates to clinically validate the radio-modulating activity of seleno-GPx, and this should be the focus of future clinical trials

At the same time, it is important to address red flags

Thus, unlike previous in vitro biochemical studies or metabolic engineering efforts, which had excluded arGSTs, we set out to confirm our hypothesis by performing coupled enzymatic reactions with 3,4- cis -leucocyanidin ( 6 ) combining clarified Escherichia coli cell lysates expressing At LDOX and the well-studied arGST Ph AN9 from petunia