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Further investigations showed that in vitro pretreatments with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a major carcinogen component of tobacco, impaired the expansion of cytotoxic T lymphocytes (CTLs) following their transfer into mice but elevated the frequency of precursor memory CLTs, resulting in a final moderate decline in memory CLTs [91]

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Foulds said quitting smoking has a bigger effect on reducing risks for a heart attack than lowering high cholesterol or blood pressure so patients should expect their doctor to assess their smoking and advise on smoking cessation medicines just as they would prescribe medicines for hypertension or hypercholesterolemia