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The resulting T H 2-dominant immune milieu is known to increase the susceptibility to allergic sensitization, whereas the minimal T H 1 function correlates with the increased susceptibility of neonates to infections (144, 145)

Further a study reported that NLRP3 inflammasome activation promotes the malignant progression of prostate cancer by enhancing cell proliferation, migration, and inhibiting apoptosis through caspase-1 activation [73]

Its antioxidant function is mediated by the reductive detoxification of hydrogen peroxide (H 2 O 2 ), reactive nitrogen species (RNS) such as peroxynitrite (ONOO ), and lipid hydroperoxides (L-OOH)

Sequence analysis can be made by polymerase chain reaction (PCR) and sequence analysis of the -glutamylcysteine synthetase genes ( GLCLC , GLCLR ) [1]