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Since PARP-1 activation is a prerequisite to initiate the parthanatos pathway 23 , we treated HBE cultures with the selective PARP-1 inhibitor BMN673 currently in clinical trials for cancer treatment 27 and exposed the cells to mainstream smoke

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Dominated by manufacturers, the US safety conversation has been myopically focused on safety ratings exclusively for people inside cars, spurring an arms race in which manufacturers design larger and larger vehicles promising protection for drivers and passengers at the expense of everyone else

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