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The importance of this mechanism was highlighted by studies where supplementation with BH 4 improved endothelium-dependent vasorelaxation in chronic smokers [37] and in isolated blood vessels [38]

The surface area for gas exchange is drastically reduced, and the lungs lose their ability to recoil and push air out

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7.2a Nicotine Replacement Therapy (NRT) Among the five NRT products approved by the US FDA for the treatment of tobacco dependence, the nicotine inhaler and spray are prescription drugs in the U.S