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These symptoms can include indigestion, pain in both arms, unusual fatigue and abdominal discomfort

These make the CYP1A2 enzyme work faster That means the enzyme breaks down clozapine quicker, so you get less effect from it But if you stop smoking that means that the enzyme slows back down to its normal speed This means that: o The liver doesnt break clozapine down as fast as it did before o Your blood level of clozapine goes up (because the body isnt getting rid of it as fast) o You may get side effects from having too high a blood level of clozapine (the same as having a higher dose) The effect can be huge, sometimes the same effect as almost doubling your dose This effect can be even more marked if you are also taking a medicine called sodium valproate If you stop smoking this effect may start in 3-5 days

By aligning with these evolving smoker preferences, light cigarettes have carved out a growing niche within an overall reduced-smoking landscape in Canada