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1998 Carcinogenesis 19 : 117124 Culp S, Roberts D, Talaska G, Lang N, Fu P, Lay Jr J, Teitel C, Snawder J, Von Tungeln L, Kadlubar F

These inflammatory cells, factors, and mediators interact to form a complex network that stimulates mucous cell metaplasia, mucus secretion, fibroblast growth and extracellular matrix protein (ECM) synthesis, airway constriction and induces AHR and airway remodeling 5-9 .In recent years, studies have found that Th17 is also essential in the pathogenesis of asthma and is closely related to the recruitment of airway neutrophils 10