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However, NPY Y1 receptor gene expression was significantly downregulated by both maternal smoke exposure and a high-fat diet, with this being reflected by reduced food intake in those offspring (Chen et al., Another important appetite regulator is the adipocyte-derived hormone leptin, which is critical for the development of neurons and neural projections between hypothalamic nuclei involved in appetite control in early life (Bouret et al., 1994

Using recent case reports, epidemiological studies, and experimental research, we highlight the role of likely etiological mechanisms such as how nicotines convulsive effects are linked to 7- nicotinic acetylcholine receptors (nAChRs), the varied clinical presentations, and the potential nicotine toxicity linked to seizures

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