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[101] [102] These effects are primarily mediated through nicotinic acetylcholine receptors (nAChRs), particularly the 7 subtype, and to a lesser extent, -adrenergic receptors (-ARs)

Fake effects at 1985 (-3 to -9 packs) are substantially smaller than real effects after 1989 (-14 to -26 packs), and a clear discontinuity appears at 1989

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According to Harvard Health Publishing, a 2021 meta-analysis pooling data from over half a million people found that those who consumed the highest amounts of fried foods were 28% more likely to develop cardiovascular problems compared to those who ate the least