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Epithelial injury in severe asthma, whether due to allergen, pollution, viral or bacterial insult, causes several changes in the response and integrity of the epithelium, leading to immune cell recruitment, inflammation, epithelial shedding ( In this review we will demonstrate how the structure and composition of the epithelium, and the basement membrane, and their interaction with the innate immune system facilitates homeostasis and protection of the airway

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