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Data from eight surveys with information on more than 215,000 people were included for analysis

Home remedies to relieve heartburn include: Lose weight if you are overweight or obese Raise the head of the bed 6 to 8 inches using blocks of wood or rubber under 2 legs of the bed or a foam wedge under the mattress Avoid foods that worsen heartburn symptoms Dont overeat Dont eat 2 to 3 hours before bed Lying down with a full stomach can make heartburn worse Wear loose clothing around the stomach area Dont smoke If lifestyle changes do not relieve symptoms of heartburn, medications used to treat the condition include: Antacids Best for mild symptoms Only work for a short time Available without a prescription Examples include aluminum hydroxide and magnesium hydroxide (Maalox), calcium carbonate and magnesium hydroxide (Rolaids), sucrose and calcium carbonate (Tums), and simethicone (Mylanta) Histamine blockers Stronger and longer-lasting than antacids Many available without a prescription Examples include cimetidine (Tagamet HB), famotidine (Pepcid AC), and nizatidine (Axid AR) Proton pump inhibitors (PPIs) Used for frequent and more severe symptoms Some are available over-the-counter (OTC) and some require a prescription Examples include esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), and rabeprazole (AcipHex) Prokinetics Used to help the stomach empty faster Examples include bethanechol (Urecholine) and metoclopramide (Reglan) Antibiotics Can help the stomach empty faster Erythromycin has fewer side effects than prokinetics

The intrinsic apoptotic pathway is regulated by the proteins of the B cell lymphoma 2 (BCL-2) family [7]