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Mol Psychiatry (2017)

[1] Neurosyphilis and ocular syphilis may also be present during this stage and others, depending on the initial point of infection: Neurosyphilis The infection spreads to the brain and spinal cord and may lead to meningeal syphilis (headache, stiff neck, nausea, and vomiting), meningovascular syphilis (headache, stiff neck, nausea, vomiting, and risk of stroke), general paresis (personality or mood changes), or tabes dorsalis (muscle failure and pain and impaired balance)

Inframe mutations are caused by deletions or insertions of nucleotides [26]

Primarily in Texas and other southern US states, terminology is unique