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Moreover, by its competitive inhibition of phosphodiesterase, leading to an elevation of myocardial cyclic adenosine monophosphate, caffeine exerts a positive inotropic action on myocardium ( As regards the possible contribution of taurine to cardiovascular negative outcomes the results of preclinical and clinical studies are inconclusive (Schaffer et al., 2014

Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction

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