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While regulation of iron metabolism-related proteins or the use of iron chelators can reduce intracellular labile Fe 2+ levels and inhibit ferroptosis, current chelators lack tissue and cellular specificity and may interfere with neurophysiological functions, thereby limiting their clinical applicability

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2024 Feb 17;73(3):57

The background rate of pancreatitis in the general population, especially among people with obesity and type 2 diabetes who use these medications, is already elevated by the underlying conditions themselves