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The 54-year-old actor played chain-smoking advertising executive Don Draper in the hit TV drama between 2007 and 2015 - and Jon admits he feels grateful not to have experienced any negative effects after spending almost a decade puffing away on prop smokes

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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)