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Epigenetic dysregulation has emerged as one of the transcriptional vulnerabilities in human cancer

This can be beneficial but may also indicate a need for dose adjustment of one or both

Proper safety and handling procedures must be observed

It also operates as an essential cofactor for various enzymes and plays a pivotal role in several important metabolic functions 3,4,5 including: Biochemical foundation of P450 enzyme detoxification in the liver, lungs, kidney and intestinal epithelia Participates in converting drugs and other toxic chemicals more water-soluble for easier excretion Participating in antioxidant defence systems Protection against free radicals Primary protectant of lens, cornea, skin and retina against radiation damage Regulating and maintaining cellular redox balance Helping metabolise oestrogens and inflammatory compounds Storing and transporting nitric oxide Storing cysteine reserves Regulating the function of proteins Involvement in DNA synthesis Participating in iron and copper transfer Glutathione tends to be found in high concentrations in all cells of the human body, particularly the liver