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This makes it difficult to accurately predict in vivo behavior from laboratory data, necessitating more extensive animal and human trials (153)

608 , 610 Dementia caregivers in the United States are more likely to have experienced depression (32.5%) or anxiety (26%) when compared with dementia caregivers from Japan (16.8% and 12.9%, respectively) or those from across Germany, Italy, Spain, France and the United Kingdom (29.3% for depression and 22.4% for anxiety)

In patients with heart failure or arrhythmias, cilostazol is generally contraindicated due to the risk of increased cardiac events (Kherallah et al

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