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Addict Biol (2016) 21(1):15970.10.1111/adb.12183 6 SorensonRLBreljeTC

Supplementary Figure 13 Correlation analysis of differentially abundant genera and pathways in healthy and OSCC samples

While its true there have been some decreases in smoking rates in certain geographic areas, the fight is far from over

Some of the most common symptoms of nicotine addiction are: Requiring more and more nicotine/tobacco to feel satisfaction Needing to smoke or use constantly as to not feel withdrawal symptoms such as irritability Using multiple forms of tobacco such as chew and cigarettes Wanting to quit but being unable to do so Continuing to use tobacco despite potential, serious health risks Nicotine Withdrawal Tobacco products, such as cigarettes and chewing tobacco, are notoriously difficult to quit and require a good relapse prevention plan