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Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 Randomized Clinical Trial

Thomas Garvey, a former FDA official and drug industry consultant who has testified against McNeil in trials, called the amount of time the FDA had taken to reach a final ruling remarkable and unusual. There are still many questions about this drug, Garvey said

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Key limitations include: Short duration of action most peptides are rapidly broken down by enzymes, requiring repeated injections or special delivery systems to maintain effect