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Among dual users, there has been a small fall since 2017 in the proportion who think vaping is less satisfying, and a small increase in those finding vaping as or more satisfying (Figure 20)

In the brain, nicotine works mostly to release other neurotransmitterslike dopamine (pleasure), norepinephrine (arousal and appetite suppression), glutamate (learning and memory), endogenous opiates, and serotonin (mood modulation)

For performer Gloria Gaynor, it took on added meaning as she was, at the time, recovering from a serious spinal injury

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