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This protective effect is independent of GSHs classical antioxidant activity and instead relies on its direct interaction with Cu + , which sequesters excess copper and prevents its aberrant binding to lipoylated proteins within the TCA cycle

Symptoms can include neck pain, arm pain, hand clumsiness, balance problems, and in severe cases issues with walking, bowel, or bladder function

This is largely in accordance with the absence of reports of IGFBP gene defects causing growth retardation in humans

(12, 13) Helping to regenerate vitamins C, E and A, all antioxidants or vitamins with antioxidant properties in their own right