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As for SFN, although it was generally safe and well-tolerated in animal models and humans, several side effects were found (i.e., insomnia, vomiting, flatulence, diarrhea, etc.)

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Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type II diabetes

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Cochrane Database of Systematic Reviews (3), CD001015

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