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Center: Center for Drug Evaluation and Research Location: The meeting will be held at the FDA White Oak Campus, 10903 New Hampshire Ave., Bldg

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Single site mutations at asparagine residues were shown to result in a functionally active yet slightly less thermally stable version of the enzyme in vitro, while knockout of all asparagine residues resulted in an accumulation of the uncleaved, propeptide form of the enzyme

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