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Clin Drug Invest 1996;11(2):90-96

This is a standard limitation of blend research and is why the peer-reviewed literature on individual components, rather than blend-specific data, is the primary reference for KLOW safety profiling

We found that glutathione (GSH) levels were associated with MTX resistance in both treated and untreated cells, suggesting a new constitutive metabolic-based mechanism of resistance to the drug

If you're dealing with chronic illness, undergoing treatment that may affect glutathione, or exposed to significant environmental toxins, your healthcare provider may recommend more frequent testing every 2-3 months