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[45] Physiology Inhaling the vaporized gas form of substances into the lungs is a quick and very effective way of delivering drugs into the bloodstream (as the gas diffuses directly into the pulmonary vein, then into the heart and from there to the brain) and affects the user within less than a second of the first inhalation

This, in turn, increases the cellular efflux of inhaled drugs, leading to reduced drug concentration within cells

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