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10.1021/bi011459o Biochemistry 104 PompellaA.CortiA.PaolicchiA.GiommarelliC.ZuninoF

Copper peptides are not the right choice for everyone, and PDRN (polydeoxyribonucleotide) is increasingly recommended as a gentler alternative for users who have reacted badly, have sensitive skin, or want regenerative benefits without the same interaction risks

These interconnected axes-Ca dysregulation, mitochondrial collapse, ERS, and NAD crisis form a self-amplifying loop that highlights multi-target therapeutic opportunities for neurodegenerative diseases (Fig

Importantly, GSH can also represent N- or O-ligands for Cu(II), assisting disproportionation and O 2 dismutase activity of Cu(I)