Monthly B12 Injection Protocols Many patients get monthly B12 injections
B12 shots are typically good for 24 hours once they are drawn up and prepared for injection, as light exposure can degrade the potency of the medication
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
More rarely, more serious reactions may occur, such as allergic reactions (urticaria, itching, shortness of breath, facial swelling), heart failure in people with pre-existing problems, or hypokalemia (low potassium levels) at the beginning of treatment due to increased hematopoiesis
