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BACH1 is highly expressed in endothelial cells of atherosclerotic plaques in both humans and mice, particularly in the aortic arch, where oscillatory shear stress is elevated

The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis

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