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Protocols shorter than five days produce minimal lasting cognitive enhancement, while protocols of 714 days produce robust, sustained effects

Human cytomegalovirus also affects astrocytes and reduces astrocytic production of thrombospondins, 261 such affecting synaptogenesis, and suppresses astrocytic expression of glutamate transporters, 262 thus decreasing neuroprotection again excitotoxic damage

Bad reasons to stack: "More is better": It usually isn't

Interestingly, systolic and diastolic blood pressure, as well as LDL-cholesterol levels were found to be significantly reduced after 6 months of Pycnogenol supplementation, compared to placebo